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PHARMACEUTICAL EXCIPIENTS

galenIQTM – the sweet pharmaceutical excipient.

galenIQTM is a highly functional filler and binder, characterized by its ease of use and applicability to a wide range of solid and liquid dosage forms such as tablets, sachets, lozenges and syrups. It is manufactured under cGMP conditions according to IPEC-PQG requirements for pharmaceutical excipients and complies with the current Ph. Eur., BP, USP-NF and JP monographs for Isomalt. galenIQTM is known for its outstanding taste properties and makes medicine taste great.

beneo-galeniq-sachet
beneo-galeniq-chewable-gum
beneo-galeniq-chewable-tablet
beneo-galeniq-pan-coating
beneo-galeniq-wet-granulation
beneo-galeniq-probiotic-tablet
beneo-galeniq-syrup
beneo-galeniq-powder-blend
beneo-galeniq-mini-tablet
beneo-galeniq-lozenge-tablet
beneo-galeniq-high-boiled-lozenge
beneo-galeniq-effervescent-tablet

Tailor-made solutions for various applications:

  • Chewable Tablet
  • Sachet / Stick Pack
  • Powder Blend
  • Lozenge Tablet
  • Probiotic Tablet
  • Mini Tablet
  • Effervescent Tablet
  • Wet Granulation
  • High Boiled Lozenge
  • Oil Carrier
  • Pan Coating
  • Syrup

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galenIQTM product range.


  • galenIQTM 721
    High soluble grade with exceptional taste properties – ideal for a broad variety of applications, such as chewable tablets, sachet fillings and many more.
  • galenIQTM 720
    Slowly dissolving grade, most commonly used in lozenge tablets.


  • galenIQTM 801
    A highly soluble refined grade, ideal throughout agglomeration and granulation processes.
  • galenIQTM 800 and 810
    Water soluble refined grades, ideal throughout agglomeration and granulation processes.


  • galenIQTM 960
    Ideal diluent and starter pellet for capsule fillings.
  • galenIQTM 981
    Best choice for sugar-free pan-coatings.
  • galenIQTM 900
    Ideal for high-boiled lozenges, leading to a very stable glass matrix.

Related Information.

BENEO galenIQ sweet tasting filler binder brochure
galenIQTM Brochure.

Discover all about our sweet, pharma-grade filler-binder.

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10 GOOD REASONS

Good reasons for galenIQTM, the multifunctional filler and binder..

The galenIQTM product range comprises different grades to serve a broad variety of solid dosage forms. Besides the grades 720 and 721 for direct
compression and dry blend applications, the 800 Series offers special powder grades of different solubilities and particle size distributions for wet
granulation, roller compaction, and other agglomeration processes. Sieved grades, such as galenIQTM 960 (starter pellets), galenIQTM 981 (for pan
coating and syrups) as well as galenIQTM 900 (for medicated candy) complete the range.

PHARMA APPLICATIONS

Applications.

galenIQTM is a high quality Isomalt, designed to meet the very specific expectations of the pharmaceutical industry.

It is a filler-binder, that combines a multitude of outstanding characteristics, suitable for a wide range of pharmaceutical
applications.

PRODUCT RANGE

Product Range.

Click here to jump directly to the specific product:
galenIQTM 721 galenIQTM 720 galenIQTM 801/800/810 galenIQTM 960 galenIQTM 981 galenIQTM 900

galenIQTM 721 (Isomalt EP, USP-NF, BP, JP)

is an agglomerated spherical isomalt

Preferred application

  • Slow to very fast disintegrating tablets
  • Chewable tablets, any kind of other tablets (also plant extracts and probiotics)
  • Dry suspensions (for Sachet and capsule fillings)

Benefits

  • High agglomerate stability and excellent flow
  • Morphology ensures homogeneity of the mix and content uniformity
  • Very low compression forces required
  • Filler and binder function – additional binders in general not required
  • Low and high dosage formulations

Material properties

  • Solubility 42 g/100 g solution at 20°C water
  • Bulk density: 0,40 g/cm³
  • Very low hygroscopic
  • Chemically extremely stable
  • Pleasant sugar-like, natural taste profile
  • Non-animal origin, sugar-free, tooth-friendly, suitable for diabetics
galeniq721-new


galenIQTM 720 (Isomalt EP, USP-NF, BP, JP)

galenIQTM 720 is an agglomerated spherical isomalt

Preferred applications

  • Slow to medium fast disintegrating tablets
  • Lozenge tablets, swallowable tablets, effervescent tablets
  • Dry suspensions (for Sachet and capsule fillings)

Benefits

  • High agglomerate stability and excellent flow
  • Morphology ensures homogeneity of the mix and content uniformity
  • Very low compression forces required
  • Filler and binder function – additional binders in general not required
  • Low and high dosage formulations

Material properties

  • Solubility 25 g/100 g solution at 20°C water
  • Bulk density: 0,40 g/cm³
  • Very low hygroscopic
  • Chemically extremely stable
  • Pleasant sugar-like, natural taste profile
  • Non-animal origin, sugar-free, tooth-friendly, suitable for diabetics
galeniq720-new

galenIQTM 801/800/810 (Isomalt EP, USP-NF, BP, JP)

galeniq801-new

Preferred application

  • Fluid Bed Agglomeration
  • Wet Granulation
  • Roller Compaction

After this pre-treatment, it can be used like galenIQTM 721

Benefits

  • Low amount of liquid required in granulation processes
  • Fast processing
  • Granules are very stable

Material properties

  • Solubility 25 g/100 g solution at 20°C water
  • d50 24 µm d90 45 µm
  • Pleasant sugar-like, natural taste profile
  • Non-animal origin, sugar-free, tooth-friendly, suitable for diabetics
galeniq800-new

Preferred application

  • Fluid Bed Agglomeration
  • Wet Granulation
  • Roller Compaction

After this pre-treatment, it can be used like galenIQTM 720

Benefits

  • Low amount of liquid required in granulation processes
  • Fast processing
  • Granules are very stable

Material properties

  • Solubility 25 g/100 g solution at 20°C water
  • d50 22 µm d90 41 µm
  • Pleasant sugar-like, natural taste profile
  • Non-animal origin, sugar-free, tooth-friendly, suitable for diabetics
galeniq810-new

Preferred application

  • Fluid Bed Agglomeration
  • Wet Granulation
  • Roller Compaction

After this pre-treatment, it can be used like galenIQTM 720

Benefits

  • Low amount of liquid required in granulation processes
  • Fast processing
  • Granules are very stable

Material properties

  • Solubility 25 g/100 g solution at 20°C water
  • d50 28 µm d90 80 µm
  • Pleasant sugar-like, natural taste profile
  • Non-animal origin, sugar-free, tooth-friendly, suitable for diabetics

galenIQTM 960 (Isomalt EP, USP-NF, BP, JP)

Preferred application

  • Dry suspension (bottle, sachet, capsule fillings)
  • Starter pellets
  • Hot-melt-extrusion

Benefits

  • Perfect flowability
  • Base material for amorphous or crystalline matrices (HME)

Material properties

  • Solubility 25 g/100 g solution at 20°C water
  • d50 380 µm
  • extremely stable against degradation by temperature, acids, APIs
  • Pleasant sugar-like, natural taste profile
  • Non-animal origin, sugar-free, tooth-friendly, suitable for diabetics
galeniq960-new

galenIQTM 981 (Isomalt EP, USP-NF, BP, JP)

Preferred applications

  • Pan-coating (sugar-free!)
  • Palatability improvement in liquid formulations

Benefits in pan-coating

  • Sugar-replacement in pan-coated goods (tablet or chewing gum)
  • Protection of center against light, humidity and friction
  • Very smooth and shiny surface

Benefits in syrups

  • Certain ability to reduce unpleasant (after-) taste, e.g. of plant extracts

Material properties

  • Solubility 42 g/100 g solution at 20°C water
  • Chemically extremely stable
  • Pleasant sugar-like, natural taste profile
  • Non-animal origin, sugar-free, tooth-friendly, suitable for diabetics
galeniq981-new

galenIQ™ 900 (Isomalt EP, USP-NF, BP, JP)

Preferred Applications

  • High-boiled lozenges

Benefits

  • Sugar-replacement in medicated hard candys
  • Deposited, stamped or filled lozenges
  • Outstanding shelf-life of final lozenge products

Material properties

  • Solubility 25 g/100 g solution at 20°C water
  • extremely stable against degradation by temperature, acids, APIs
  • Pleasant sugar-like, natural taste profile
  • Non-animal origin, sugar-free, tooth-friendly, suitable for diabetics
galeniq900-new

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1) High compressibility

With galenIQTM only low compaction forces for high tablet hardness is required. The directcompressible types of galenIQTM exhibit first rate tableting properties due to their excellent compactability and high dilution potential.

The figure shows tablet hardness as a function of compression force, both galenIQTM grades 720 and 721 need only extremely low compression forces to obtain very hard tablets. This is due to their binder properties, which is a helpful advantage in any kind of tablet formulation. It also protects pressure sensitive APIs. Furthermore, low compression forces help to protect the machine and tooling against fast mechanical wear and prevent the blend from segregation in the feed hopper.

At high concentrations of poorly compressible API in the formulation, the galenIQTM enables the production of very hard tablets at extremely low compression forces. This indicates that adding further binder components may not be necessary in these kinds of formulations, which eases the formulation work in all aspects.

2) Bitterness reduction

galenIQTM reduces the bitter taste of APIs, it masks the unpleasant taste of e.g. plant extracts and contributes to a pleasant, well-balanced taste profile and mouthfeel of the final pharmaceutical or nutraceutical product.

The figure shows the results of a study (3) with artificial sensors, that are designed to simulate the taste quality that persons perceive. This electronic tongue was used to measure the comparative bitterness reduction of a quinine hydrochloride solution. Interestingly in comparison to Maltitol, Mannitol and Sucrose, the addition of Isomalt (galenIQTM grade 721) in concentrations as low as 3 to 6% w/w a significantly higher bitterness reduction.

(3): Luhn O., Masaaki H., Cepok M-B., Black M, Bernard J.; PharmaChem, 2014, 9-10, 8-103

3) Excellent flow and mixing properties

With a well-defined particle size distribution, galenIQTM 720 and 721 provide outstanding flow and mixing properties.galenIQTM is the perfect excipient for easy tableting and for stick pack filling because no glidant is necessary.

Agglomerated galenIQTM is a white, odourless and water soluble material. The agglomerated grades galenIQTM 720 and 721 feature a unique morphology.  The large specific surface structure of the galenIQTM grades 720 and 721 eases the formulation of powder blends with different API particle sizes – be it 100 mesh or 10 µm or both at the same time.

The very porous and large specific surface areas enable the incorporation of high concentrations of active ingredients on the one hand without compromising the flow properties of the final mixture. On the other hand, these surface structures prevent segregation even in very low dose blends during the whole process, thus ensuring the homogeneity of the mixture and subsequently the required content uniformity. Both grades, galenIQTM 720 and 721 provide excellent flowability as well as powder characteristics and differ only in solubility.

4) Sugar-like sweet taste

The galenIQTM taste profile is very close to sucrose, it has an intense but well-balanced sweet taste. galenIQTM provides a good mouthfeel for chewable tablets, suckable tablets, stick packs and many more dosage forms.

Patient friendly dosage forms are a prequisite for the effective treatment of diseases especially when therapy time is prolonged. If the taste attributes of the medicine play a determining role, special pharmaceutical excipients are often used taking into account their sensory attributes such as sweetness and texture. In this respect sucrose is of significant importance, as it is an integral part of our food since primeval times and has become the epitome of the intimate taste impression for “sweet“. Therefore sucrose serves as the benchmark for all comparisons of sweetening power and the taste impression of sweeteners.

In the development course of pharmaceutical dosage forms, sugar alcohols have become the preferred choice over sucrose when properties like suitability for diabetics and tooth friendliness are in the foreground. Isomalt is the only sugar alcohol that is derived from sucrose. It is mainly due to this reason that galenIQTM has a sweetness and taste profile very close to sucrose. Isomalt does not have any significant off-taste of aftertaste.

5) Chemically and mechanically extremely stable

Both galenIQTM grades 720 and 721 (for direct compression and dry blends) exhibit high agglomerate stability, even if a high shear blending process is used. The figure shows that there is no significant change in particle size over blending time and flowability is not affected. galenIQTM 720 exhibits high agglomerate stability during the process of mixing.

Besides the mechanical, also the chemical stability of galenIQTM plays an important role. Based on its stable chemical structure, it does not react with other components – for example, with amino acids to form Maillard Reaction Products, nor is degraded by heat, acids or anzymes. galenIQTM even protects moisture sensitive APIs.

6) galenIQTM is a multifunctional filler and binder

The galenIQTM product range comprises different grades to serve a broad variety of solid dosage forms.

Besides the grades 720 and 721 for direct compression and dry blend applications, the 800 Series offers special powder grades of different solubilities and particle size distributions for wet granulation, roller compaction, and other agglomeration processes.

Sieved grades, such as galenIQTM 960 (starter pellets), galenIQTM 981 (for pan coating and syrups) as well as galenIQTM 900 (for medicated candy) complete the range.

7) galenIQTM is the No 1 in medicated candy

Lozenges provide an effective unit dosage amount of e.g. an antitussive, decongestant, antihistamine or expectorant ingredient which is effectively released by sucking the lozenge. Its physiological and physical properties as well as its chemical stability makes galenIQTM 990 the excipient of choice for high-boiled lozenges. galenIQTM based lozenges are very stable against water absorption as well as influences by API or temperature.

galenIQTM provides a long lasting effect due to slow dissolution. Dissolution tests have shown, that a galenIQTM lozenge lasts approx. one third longer in the oral cavity compared to a sucrose/glucose syrup-based lozenge of the same weight, size and shape (see figure).

The production process is almost similar to that of high-boiled lozenges based on sucrose / corn syrup. Ask our expert for technical support!

8) galenIQTM is low hygroscopic

galenIQTM does not absorb water and thus ensures long-time stability of your dosage form. With this characteristic, isomalt provides optimal protection even for moisture-sensitive active pharmaceutical ingredients.

Furthermore, the low hygroscopic nature, combined with an anti-caking property, galenIQTM eases production processes such as mixing, agglomeration or tableting, and will help to eliminate the need for costly protective packaging.

9) galenIQTM is suitable for pharmaceuticals, supplements and medical devices

galenIQTM complies with the ISOMALT monograph of the current Pharmacopeias (Ph.Eur., BP, USP-NF, JP) and has an import licence for China. galenIQTM also complies with the general standards food safety and quality, which makes it suitable for use in food and food supplements. Furthermore, galenIQTM is listed under its generic name Isomalt in the FDA Inactive Ingredients Database (IIG): http://www.accessdata.fda.gov/scripts/cder/iig/

10) galenIQTM has a natural source

galenIQTM is produced from sugar, which is derived from sugar beet. galenIQTM is of non-animal origin and GMO free.

The figure shows production steps of galenIQTM: In a first step, an enzymatic transglucosidation transforms sucrose to isomaltulose. In a second step, a catalytic hydrogenation creates galenIQTM(ISOMALT) .

Chewable Tablet
beneo-galeniq-chewable-tablet

WHY galenIQTM

  • Mixability, Flowability
  • Compressibility
  • TASTE: sweet, balanced
  • Mouthfeel: smooth, pleasant
  • Appearance: white, shiny

galenIQTM grade

  • 721 by direct compression

READ MORE

Sachet / Stick Pack
beneo-galeniq-sachet

WHY galenIQTM

  • Flowability, no further agent necessary
  • Mixability
  • TASTE: sweet, balanced
  • Mouthfeel: smooth, pleasant
  • Sugar free, tooth friendly

How

  • Direct blend with other ingredients.

galenIQTM grade

  • 721 by direct blending

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Power Blend
beneo-galeniq-powder-blend

WHY galenIQTM

  • Flowability, no further agent necessary
  • Mixability
  • TASTE: sweet, balanced
  • Mouthfeel: smooth, pleasant
  • Completely soluble in water
  • Sugar free, tooth friendly

galenIQTM grade

  • 721 or 720 by direct blending

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Lozenge Tablet
beneo-galeniq-lozenge-tablet

WHY galenIQTM

  • Compressibility / compactability
  • Very hard tablets
  • Slow dissolution: Longlasting effect
  • TASTE: sweet, balanced
  • Mouthfeel: smooth, pleasant
  • Sugar free, tooth friendly

How

  • Direct compression

galenIQTM grade

  • 720

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Probiotic Tablet
beneo-galeniq-probiotic-tablet

WHY galenIQTM

  • Low water activity
  • Mixability, Flowability
  • Compressibility
  • TASTE: sweet, balanced
  • Mouthfeel: smooth, pleasant
  • Appearance: white, shiny

galenIQTM grade

  • 721 by direct compression

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Mini Tablet
beneo-galeniq-mini-tablet

WHY galenIQTM

  • use of galenIQ™ 721 without pre-treatment
  • Monodispers, homogeneous
  • no electrostatic effects
  • TASTE: sweet, balanced, smooth mouthfeel
  • Appearance: white, shiny

galenIQTM grade

  • 721

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Effervescent Tablet
beneo-galeniq-effervescent-tablet

WHY galenIQTM

  • Stable in effervescent formula
  • Completely soluble in water
  • Compressibility, Mixability, Flowability
  • TASTE: sweet, balanced

galenIQTM grade

  • 721 by direct compression

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Wet Granulation
beneo-galeniq-wet-granulation

WHY galenIQTM

  • Fast and easy processing
  • TASTE: sweet, balanced

galenIQTM grade

  • 800, 801 or 810

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High Boiled Lozenge
beneo-galeniq-high-boiled-lozenge

WHY galenIQTM

  • No. 1 in sugar-free candys
  • Easy processing, only 1 main ingredient
  • Extremely stable
  • Sugar-like TASTE

galenIQTM grade

  • 900

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Oil Carrier
beneo-galeniq-oil-carrier

WHY galenIQTM

  • galenIQTM acts like a sponge which can absorb oil
  • galenIQTM provides excellent taste characteristics

galenIQTM grade

  • 721 by direct or high-shear blending

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Pan Coating
beneo-galeniq-pan-coating

WHY galenIQTM

  • Easy processing
  • Stable pan coated final form
  • TASTE: sweet, balanced
  • Mouthfeel: smooth, pleasant
  • Appearance: white, shiny.
  • Sugar-free

galenIQTM grade

  • 981 in suspension
  • Addition of galenIQ™ 801 during initial phase recommended

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Syrup
beneo-galeniq-syrup

WHY galenIQTM

  • Improve Palatability

How

  • Add 5-10 % galenIQTM to reduce unpleasant aftertaste of API (e.g. plant extracts, bitter APIs)

galenIQTM grade

  • 981 as taste enhancer

READ MORE

You can use galenIQTM for many more applications. Our experts are keen to assist you, please get in touch with us.

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